Ozempic injection What are the long-term side effects of Ozempic?How long does it take to lose weight with Ozempic?Ozempic starts to work right away, but you may not see significant weight loss for several months. Ozempic has led to weight loss and blood sugar control in studies ranging from 30 to 56 weeks in length, when used in addition to diet and exercise.It has been shown to lead to weight loss in patients with type 2 diabetes, but Ozempic is not specifically FDA-approved as a weight-loss 
medication.Learn more: How long does it take for Ozempic to work?How can you lose the most weight with Ozempic?Staying active and eating a healthy diet low in fat, sugar, and calories is the best way to lose weight with Ozempic. Your doctor may suggest you meet with a dietitian to help you learn about meal planning and food choices.An exercise routine on most days of the week can boost your weight loss, your mood, and help you meet your targets. If you have not exercised in a while, or have any health conditions, speak with your healthcare provider about the best way to ease into an exercise routine. Working with a trainer or a physical therapist may prove beneficial, especially at the outset.Also, follow your doctor’s dosing instructions exactly. You will start treatment with lower doses to help you tolerate the stomach side effects like nausea, vomiting, diarrhea, stomach pain, or constipation. These side effects are typically mild to moderate and lessen over time.Some foods may worsen your nausea or other stomach side effects while taking Ozempic. If you are experiencing stomach side effects, try:Eating smaller meals and eating more slowlyAvoiding foods high in fat, fried or greasy foods, and unhealthy “fast-foods” Cutting back on spicy or acidic foods, or caffeine, if they bother youAvoiding or limiting alcoholic beverages (no more than one serving per day for women or two servings per day for men)Drinking plenty of fresh water throughout the dayLimiting excessive sugar intake.These foods or drinks may also affect your blood sugar control and slow down weight loss.Learn More: Taking Ozempic: What foods should you avoid?It may take about 2 to 3 months to reach your Ozempic maintenance dose, so going slowly, as directed, can help you tolerate the medicine and prevent you from having to stop treatment altogether. Higher doses have been shown to lead to greater weight loss.Does Ozempic cause side effects that lead to weight loss?Stomach side effects are common when starting treatment with Ozempic but decrease over time in most patients. At the beginning of treatment, this may affect your appetite. In one study, 58% of patients (231 of 402) receiving a semaglutide 1 mg dose experienced mild to moderate gastrointestinal side effects.The most common side effects reported in at least 5% of patients treated with Ozempic are: Nausea, Vomiting, Diarrhea, Abdominal (stomach area) pain, Constipation. In September 2023, the FDA updated the warnings for Ozempic to emphasize that an intestinal blockage called an ileus has been reported as a possible side effect. An ileus results in the failure of the intestinal contents to pass through the gut.An ileus may lower your appetite and cause symptoms like nausea, vomiting, stomach pain, and bloating, which may make eating uncomfortable or irritating. Contact your healthcare provider right away if you have stomach side effects that worry you.Can I use Ozempic for weight loss if I don’t have diabetes?Yes, in many cases non-diabetics can use Ozempic for weight loss. Studies with semaglutide, the active ingredient in Ozempic, have shown that weight loss can occur in people with or without type 2 diabetes.Your healthcare provider may decide to prescribe Ozempic “off-label” for you for weight loss. Off-label means it’s not specifically approved by the FDA for this use or listed in package labeling, but your doctor has decided it may still have a positive benefit and can prescribe it. However, in most cases, your insurance will not approve this use if you don’t have type 2 diabetes because weight loss alone is not FDA-approved for Ozempic.But your insurance may pay for Wegovy for weight loss, and you should check. Wegovy is semaglutide, the same active medicine that’s in Ozempic, but is specifically approved for weight loss in adults and children 12 years and older. It can be used in people with or without type 2 diabetes and it’s given at a slightly higher dose than Ozempic.In the 68-week-long STEP-2 study in adults with overweight or obesity and type 2 diabetes, Wegovy 2.4 mg injected once a week was shown to lead to significantly greater weight loss (about a 10% weight loss) compared to a placebo (3.4% weight loss).In another Wegovy study in adults with either obesity or overweight (average starting weight of 232 lb), patients with weight-related medical conditions received either Wegovy 2.4 mg or a placebo (an inactive injection). The average weight loss in the 68-week-long study showed about a 35 lb (15%) weight loss with Wegovy compared to 6 lb (2.5%) with placebo.How do you qualify for Ozempic for weight loss?In the U.S., you will most likely qualify for Ozempic coverage for weight loss if you are also being treated for type 2 diabetes. Most insurance companies do not cover this product for weight loss alone because it is not specifically approved by the FDA for that use, even if your doctor has written you a prescription.Ozempic use for weight loss is considered “off-label” (not an FDA-approved use). Insurance companies may not pay for “off-label” or unapproved uses of drugs, even though they may be effective.Because Ozempic is a medicine typically used long-term, costs can be significant if you must fully pay with cash for this medicine for weight loss. There are no generic alternatives for Ozempic at this time.Related: Ozempic Price Guide and Coupons. This is not all the information you need to know about Ozempic (semaglutide) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.References Read next Ozempic Mounjaro Wegovy & Zepbound: Weight Loss Compared Ozempic, Mounjaro, Wegovy, and Zepbound can all lead to long-term weight loss, but only Wegovy and Zepbound are approved by the FDA for this use. In studies, Zepbound has led to a 21% weight loss in adults using the highest dose, while Wegovy has led to about a 15% weight loss.Continue reading Wegovy vs Ozempic: Which is Right for You? How long does it take for Ozempic to work?See also: Aimovig. Learn about Aimovig (erenumab-aooe), a once-monthly, injectable medication that can be …Reviews & ratings 5.2 / 10656 Reviews Featured Mounjaro. Mounjaro is used for type 2 diabetes to help lower blood sugar levels. 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It temporarily improves the …Reviews & ratings4.9 / 1012 ReviewsOnabotulinumtoxinAOnabotulinumtoxinA information from pharmacyaesthetic.com includes OnabotulinumtoxinA side effects ..How does Ozempic work for weight loss?Medically reviewed by Leigh Ann Anderson, Pharmacy Aesthetic. Last updated on Sep 15, 2025.Official Answer by pharmacyaesthetic.com Key Takeaways Ozempic (semaglutide) works by acting like a natural hormone found in your body called glucagon-like peptide-1 (GLP-1). It helps with weight loss by slowing down the rate at which food travels through your digestive tract. Reducing your appetite can lead to weight loss. It also plays a role in regulating your blood sugar and natural insulin levels.In clinical studies, patients lost an average of 14 lbs (6.4 kg) when Ozempic 2 mg was given over 40 weeks, but your individual results may vary.Approved Uses Ozempic is approved to treat type 2 diabetes to help you manage your blood sugar control. It helps prevent large blood sugar spikes. And you may feel less hungry when you do not have wide swings in your blood sugar.Studies have found that people who use Ozempic to treat type 2 diabetes often lose weight as a secondary benefit. Even though it’s not approved for this use.It’s also approved to help reduce the risk of major cardiovascular (heart) events a heart attack. stroke or death in adults with type 2 diabetes mellitus with known heart disease.It may also be prescribed to reduce the risk of kidney disease worsening, kidney failure (end-stage kidney disease), and death due to cardiovascular (heart) disease. disease in adults with type 2 diabetes mellitus and chronic kidney disease.It’s not known if is safe and effective for use in children.Both Ozempic and Wegovy are manufactured by Novo Nordisk.Is Ozempic approved for weight loss? Ozempic is not FDA-approved for weight loss. but was shown in studies to help people lower their blood .sugar and lose weight when it was used to treat type 2 diabetes. The primary benefit studied in the majority of Ozempic . studies was the mean change in A1C (long-term blood sugar control) in patients with type 2 diabetes. Weight loss was looked at as a secondary endpoint in Ozempic studies, with people losing on average 14 lbs. after about 7 to 12 months.If you are looking for a medicine specifically approved for weight loss, .a brand name drug called Wegovy may be an option.Wegovy injection contains a slightly higher dose of semaglutide (the same active ingredient that’s in Ozempic), but is FDA-approved to help people with obesity or who are overweight lose weight and keep it off over the long-term. Wegovy is also approved for other uses as noted.How much weight can you lose with Ozempic?Results from studies in patients with type 2 diabetes show that people lost up to 14 lbs (6.4 kg) on average using the 2 mg weekly dose over 40 weeks when compared to a placebo.Significant weight loss has also been seen when Ozempic was compared to other diabetes treatments like Trulicity (dulaglutide) or Januvia (sitagliptin).StudiesOzempic is given as a once-weekly injection under the skin in the stomach area, the thigh, or the upper arm using an autoinjector pen. It’s used on the same day each week and you can take it with or without food. Your healthcare provider can teach you or a caregiver how to inject the medicine so it can be used at home.The results below are from clinical studies that can give you an idea of how much weight people lost when using Ozempic for blood sugar control.Ozempic used alone vs. placeboIn a study that lasted 30 weeks in 388 adult, the mean baseline body weight was 89.1 kg, 89.8 kg, 96.9 kg in the placebo, Ozempic 0.5 mg and Ozempic 1 mg arms, respectively.Patients using the weekly Ozempic 0.5 mg dose lost an average of 8 lb (3.8 kg) and those using the weekly 1 mg weekly dose lost an average of 10 lb (4.7 kg), compared to those taking placebo (an injection with no medicine) who lost about 3 lb (1.2 kg).Studies also found that people with type 2 diabetes lost at least double the weight with Ozempic when compared to Trulicity (dulaglutide), another glucagon-like peptide-1 (GLP-1) agonist type 2 diabetes medicines, when given over 40 to 56 weeks.SUSTAIN 7In a 40-week long study (SUSTAIN 7) in 1,201 adults with type 2 diabetes who were also taking metformin, people using Ozempic 1 mg lost close to 13 lb (6 kg) compared to 6 lb (2.7 kg) for the group using Trulicity 1.5 mg weekly.The lower 0.5 mg weekly dose of Ozempic also led to more weight loss than the 0.75 weekly dose of Trulicity: 9.3 lb (4.2 kg) vs. 4.6 lb (2.1 kg) on average.SUSTAIN 4SUSTAIN 4 was a 
30-week long study in 1089 insulin-naïve adult patients with type 2 diabetes on metformin ± a sulfonylurea. Two groups received Ozempic 0.5 mg or 1 mg. The other group received study-titrated Lantus (insulin glargine). The average weight of patients at the start of the study was 206 lbs (94 kg).Overall, patients in the Lantus group gained about 2 lb (1 kg) at 30 weeks, compared to a weight loss of 7.1 lbs (3.6 kg) and 10.4 lbs (4.7 kg) with the 0.5 or 1 mg Ozempic dose, respectively.SUSTAIN FORTESUSTAIN FORTE was a 40-week long study in adult patients with type 2 diabetes on metformin ± a sulfonylurea. The groups received either Ozempic 1 mg or 2 mg. The average weight of patients at the start of the study was about 219 lbs (100 kg).Overall, patients in the Ozempic 1 mg group lost 12.5 lb (5.7 kg) and those in the 2 mg group lost about 14 lb (6.4 kg). The difference between treatment arms (1 mg or 2 mg) in body weight change from baseline at week 40 was not statistically significant.In Ozempic studies, not all people lost weight and some people did gain weight. You may also be taking other medicines like a sulfonylurea (like glipizide or glyburide), or insulin, which can also add to weight gain. Metformin does not usually lead to weight gain, and may help promote weight loss in some individuals.Studies suggest that higher doses of Ozempic or semaglutide may lead to greater weight loss. The Wegovy brand of semaglutide contains a higher dose of semaglutide, is FDA-approved for weight loss and may result in a greater weight loss for you. In studies with Wegovy, adults lost around 15% of their body weight, equal to about 35 lb (16 kg).People respond to medicines differently, so your weight loss may not be the same as others. Treatments for type 2 diabetes are used in addition to an appropriate diet and exercise regimen for the best effect. Talk to your healthcare provider about the best medicine to help you lose weight and keep it off.Related questionsMounjaro vs Ozempic: Which is right for you?Ozempic Side Effects.Reviews & ratings5.8 / 10506 ReviewsRelated medical questionsHow many doses are in an Ozempic pen?Which GLP-1 drug is best for weight loss?Do Ozempic, Wegovy, Mounjaro & Zepbound cause hair loss?Can you switch between Ozempic and Mounjaro?Does Ozempic need to be refrigerated?What happens when you stop taking Ozempic?Will my insurance cover the cost of Ozempic?Do GLP-1 drugs like Ozempic and Mounjaro cause sulfur burps?Can you get tirzepatide from a compounding pharmacy?When is the best time of day to take Ozempic?Saxenda vs Ozempic: For Weight Loss?Why am I not losing weight on Ozempic?Are there natural alternatives to Ozempic for weight loss?Can you buy Ozempic over the counter?Does Ozempic cause muscle loss and how to prevent it?Where and how should Ozempic be injected?Ozempic and Surgery: When to stop and restart?Ozempic Face: What causes it and how to prevent it?Rybelsus vs Ozempic for weight loss: Which to choose?How long does Ozempic last in your system?How long can you stay on Ozempic?How does Ozempic affect blood pressure?How do Ozempic and Metformin compare for diabetes?Drug informationOzempic Information for ConsumersOzempic prescribing info & package insert (for Health Professionals)Side Effects of Ozempic (detailed)Ozempic user reviews (1,627)Related support groupsOzempic (115 questions, 231 members)Weight Loss (Obesity/Overweight) (882 questions, 1,518 members)Medical DisclaimerAttribution & citationsTerms & privacyTerms of useEditorial policyPrivacy policySupportHelp centerSitemapContact usAccessibilitypharmacyaesthetic.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 5 Oct 2025), Cerner Multum™ (updated 27 Oct 2025), ASHP (updated 12 Oct 2025) and others.Certified by TRUSTeVerified by TAGThis website is certified by pharmacyaesthetic.com Click to verify.AdChoices – Ad privacy informationCopyright © 2000-2025 pharmacyaesthetic.com All rights reserved.